Stop 1 of 7 · Day 0 · 14:10
Recognize sepsis early
What happens
T 38.9 °C, HR 112, BP 104/62, RR 24, SpO2 89% on room air. Crackles at the right base; chest X-ray shows right lower lobe consolidation. WBC 16.8, lactate 2.6 mmol/L, creatinine 1.4 (baseline 0.9). The team treats this as pneumonia with sepsis: two sets of blood cultures, then ceftriaxone plus azithromycin within the hour, oxygen to SpO2 92–96%, and a crystalloid bolus with reassessment.
Who is involved
- ED physician
- ED nurse
- Respiratory therapist
- Pharmacist
Teaching point
Sepsis is life-threatening organ dysfunction caused by a dysregulated response to infection. Do not let a single score rule it out: the Surviving Sepsis Campaign recommends against using qSOFA alone as a screening tool. Cultures should come before antibiotics only when that does not meaningfully delay them.
MDM: 67M w/ T2DM, HTN, former smoker with RLL pneumonia and sepsis (new O2 need, AKI, lactate 2.6). Not hypotensive. - Blood cx x2 drawn 14:25, then ceftriaxone 1 g IV + azithromycin 500 mg IV started 14:40 - 1 L balanced crystalloid, reassess vitals/exam; repeat lactate 2 h - O2 via NC, goal SpO2 92-96% - Severity: CURB-65 = 2 (age, BUN 28) + new O2 need Dispo: admit to hospitalist, telemetry.